A new approach to detecting cancer signals through a single blood sample
The Wright Practice is preparing to become one of the first private GP clinics in the UK to offer the Galleri multi-cancer early detection blood test.
Galleri is designed to identify a signal associated with more than 50 types of cancer—many of which do not currently have a routine screening programme—and predict where in the body that signal is most likely to have originated.
It represents an important development in cancer detection, but it is not a definitive cancer diagnosis and does not detect every cancer. At The Wright Practice, it will therefore be offered as part of a medically supervised cancer-risk assessment, with careful counselling before testing and appropriate clinical support once the result is available.
Galleri will be available at our clinic at 101 Harley Street.
The Galleri test is a multi-cancer early detection blood test developed by GRAIL.
Cancer cells can release small fragments of genetic material, known as cell-free DNA, into the bloodstream. Galleri analyses patterns of chemical changes—called methylation patterns—within this DNA.
The test is designed to answer two questions:
This “cancer signal origin” prediction helps doctors decide which diagnostic investigations should be arranged next.
Galleri is intended to complement existing screening and clinical assessment. It does not replace mammograms, cervical screening, bowel screening, prostate assessment, lung screening or investigation of concerning symptoms. If you’re unsure which routine tests are right for you, our range of private blood testing services can help build a fuller picture alongside Galleri.
Galleri is principally intended for adults at increased risk of cancer, particularly those aged 50 and over.
Testing may be considered for people who:
Age remains one of the strongest risk factors for cancer. This means that the potential usefulness of multi-cancer testing generally increases as people get older. It’s a key reason Galleri is often considered as part of a wider approach to healthy ageing and longevity.
Galleri is not generally recommended for people who are pregnant, aged 21 or younger, or currently undergoing active cancer treatment.
Suitability will be considered individually during your consultation.
Galleri is designed primarily for people without symptoms. It should not delay or replace diagnostic investigation when symptoms are already present.
If you have unexplained or persistent symptoms—such as a new lump, abnormal bleeding, unexplained weight loss, a persistent cough, altered bowel habits, difficulty swallowing or unexplained pain—you should arrange a clinical assessment promptly.
A “No Cancer Signal Detected” result would not safely exclude cancer as the cause of symptoms.
At The Wright Practice, symptomatic patients will first receive an appropriate medical assessment. We can then arrange targeted blood tests, imaging or specialist referral rather than relying upon a screening test.
Established screening programmes are available for only a limited number of cancers. Many cancers are currently identified only after they cause symptoms.
Galleri is designed to detect a shared signal across more than 50 cancer types, including several for which there is no routine population-screening programme.
These include cancers affecting areas such as the:
The ability to test for numerous cancer signals using one blood sample is what distinguishes multi-cancer early detection testing from conventional screening procedure.
However, detection varies considerably according to the type and stage of cancer. Some cancers release more DNA into the bloodstream than others, and earlier cancers are generally more difficult to detect.
There are two principal possible results.
This means the test did not identify a cancer-associated signal in the blood sample.
This is reassuring, but it does not guarantee that cancer is absent. Galleri does not detect every cancer, and cancers that release little DNA into the bloodstream—particularly some early-stage cancers—may not be detected.
You should therefore continue all routine cancer screening and seek medical advice about any new or persistent symptoms.
This means Galleri has identified a pattern that may be associated with cancer.
The result will normally include a prediction of the most likely cancer signal origin. This helps guide the next stage of investigation, which may include imaging, endoscopy, specialist assessment or tissue biopsy.
A Cancer Signal Detected result is not itself a cancer diagnosis. Further investigations are always required, and occasionally no cancer will ultimately be found.
Galleri has demonstrated high specificity in published validation studies. This means that most people who do not have cancer receive a No Cancer Signal Detected result.
Its sensitivity is more variable. The test is more likely to detect certain cancer types and more advanced cancers than very small or early-stage cancers.
This creates two important limitations:
The test’s prediction of where a detected cancer signal originated is intended to guide further investigation, but it is not always correct.
We will explain these limitations clearly before proceeding so that you can decide whether testing is right for you.
Galleri has been evaluated in the NHS-Galleri trial, involving more than 140,000 participants.
The trial’s primary endpoint—a statistically significant reduction in the combined number of stage III and stage IV cancers—was not met. Some secondary findings, including results relating specifically to stage IV cancers, were more encouraging, but they require cautious interpretation.
The trial has therefore not established that Galleri reduces cancer mortality or justified its use as a population-wide NHS screening programme. Longer-term follow-up remains important.
We believe patients considering the test deserve a balanced explanation of both its potential and the uncertainties that remain. Galleri is a promising additional detection tool, not a replacement for established screening or a guarantee against cancer.
Galleri will not be offered as an isolated blood test without clinical context.
Our service will include:
A doctor will review:
We will also check whether any conventional screening or targeted investigation is due. This consultation often sits naturally alongside our Wellperson Health Assessments, giving a more complete view of your overall health.
Your sample will be collected by our clinical team and processed according to the test provider’s requirements.
Your result will be reviewed in the context of your complete clinical picture rather than released without explanation.
If no cancer signal is detected, we will explain what routine screening and health surveillance should continue.
If a cancer signal is detected, we will discuss the result promptly and coordinate the appropriate diagnostic pathway. This may include imaging and referral to an experienced specialist.
A positive Galleri result requires further investigation and cannot be confirmed by repeating the blood test alone.
Galleri should be used alongside—not instead of—established cancer screening.
Depending on your age, sex and individual risk, this may include:
Galleri also differs from genetic testing. Genetic testing looks for inherited variants that may increase your future risk of developing cancer. Galleri looks for a signal that may indicate cancer is already present. To understand whether an inherited-risk approach is relevant to you, take a look at our genetic testing service.
In selected patients, both approaches may form part of a broader personalised cancer-prevention strategy, which we can help coordinate through our Cancer and Heart Screening programme.
Galleri may provide:
Its greatest potential lies in identifying cancers that might otherwise remain undetected until symptoms appear.
It is important, however, to balance this potential against the possibility of false reassurance, anxiety or further investigations that ultimately do not identify cancer.
We recognise that receiving this result may be worrying.
Dr Dan and the team will contact you promptly, explain the finding and arrange a follow-up consultation. We will review the predicted cancer signal origin and determine which specialist or investigation is most appropriate.
This may involve:
We can coordinate referrals across our network of leading London specialists and remain involved throughout the investigation.
Our role is not simply to provide the blood test. It is to help you understand the result and navigate what happens next.
A No Cancer Signal Detected result is reassuring, but it does not provide an “all clear.”
You should continue to:
Your follow-up consultation provides an opportunity to review these points and create a practical prevention and screening plan.
The Wright Practice will be among the first private GP clinics in the UK preparing to introduce the Galleri multi-cancer early detection test.
Our service will combine advanced testing with careful clinical selection, balanced pre-test counselling and doctor-led follow-up at every stage.
To register your interest:
Call: 0207 139 1833
Email: info@thewrightpractice.com
Visit: The Wright Practice, 101 Harley Street, London W1G 6AH
Galleri is a screening test and is not diagnostic. It does not detect every cancer, and false-positive and false-negative results can occur. A Cancer Signal Detected result requires further diagnostic investigation. A No Cancer Signal Detected result does not exclude cancer. Galleri must not replace routine cancer screening or the investigation of symptoms.
Wow! Dr. Dan was extremely knowledgeable and attentive to my health and well being. I’m so glad to have found him!
I have been going to Dr Wright for a number of years now. He is highly knowledgeable, compassionate, open minded and efficient, I couldn’t recommend him highly enough
I have been a patient of Doctor Dan for some time and continue to consult with him despite having left the UK. Dan has the enthusiasm and energy of a young man, whilst taking the holistic “physician” approach of an old school family doctor, equipped with the most modern insights and technology.
Dr Jain was great. Expert knowledge with practical advice
No. Galleri can identify a signal that may be associated with cancer and predict its likely origin. Diagnostic imaging, specialist assessment or biopsy is required to confirm whether cancer is present.
No. A No Cancer Signal Detected result reduces concern but cannot exclude every cancer. False-negative results occur, particularly because some cancers release little DNA into the blood.
No. You should continue all screening recommended for your age, sex and risk profile.
Galleri should not be used to delay investigation of symptoms. If you have concerning symptoms, we will assess these first and arrange targeted investigations.
No. It is not a hereditary cancer-risk test. Where family history suggests an inherited cancer syndrome, genetic counselling or genetic testing may be more appropriate.
The optimal interval remains under evaluation. Galleri has generally been studied as an annual test, but repeat testing should be discussed with your doctor according to your risk and the evolving evidence.
The cancer signal origin is a prediction and may occasionally be incorrect. If initial investigations are negative, broader assessment may be required.
Galleri has been evaluated in a large NHS trial, but it is not currently part of routine NHS population screening. NHS eligibility and future policy may change as further evidence emerges.
Pricing for The Wright Practice Galleri service will be confirmed before launch. The total cost will reflect the test, blood collection, clinical assessment and doctor-led interpretation.
Additional investigations following a Cancer Signal Detected result are not included and may be covered separately through private medical insurance or self-funding. Patients enrolled in our Private GP Membership may benefit from coordinated pricing and priority follow-up.
Yes. You can register your interest and our team will contact you when appointments become available.
Book online | Call: +44 (0)207 139 1833 | Email: info@thewrightpractice.com
101 Harley Street, London, W1G 6AH
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