Modern weight management is about much more than willpower or a number on the scales. At The Wright Practice, we take a medical and personalised approach, looking at the biological, hormonal, metabolic and lifestyle factors that influence weight.
Where appropriate, treatment may include prescription medication alongside practical support with nutrition, exercise, sleep, muscle preservation and long-term maintenance.
Body weight is regulated by a complex interaction between genetics, appetite hormones, metabolism, sleep, stress, medication, physical activity and our environment. These systems influence how hungry we feel, how quickly we become full and how strongly the body resists weight loss.
This helps explain why two people following similar diets and exercise programmes can experience very different results—and why maintaining weight loss can sometimes be harder than losing weight initially.
Obesity is increasingly recognised as a chronic medical condition rather than simply a lifestyle issue. Nutrition and activity remain important, but some people benefit from a more comprehensive approach that addresses the biological drivers of appetite and weight regain.
Our aim is not rapid or indiscriminate weight loss. We focus on improving metabolic health, reducing future disease risk, preserving muscle and achieving results that can be maintained safely.
An assessment may be helpful if you:
Medication is not necessary or suitable for everyone. A consultation allows us to review the full clinical picture and discuss the benefits, limitations and alternatives.
Every patient begins with an individual medical assessment. This may include:
We then agree a personalised plan. This may involve lifestyle measures alone or, where clinically appropriate, prescription medication with structured follow-up.
GLP-1-based medicines influence biological pathways involved in appetite, fullness, cravings and blood-sugar regulation. Some treatments are weekly injections, while newer options are taken as daily tablets.
The available formulation is only one consideration. The most suitable option depends on medical history, treatment goals, previous experience, side effects, daily routine and individual preference.
| Treatment | Active ingredient | Form | Frequency | Practical consideration |
|---|---|---|---|---|
Wegovy | Semaglutide | Injection | Once weekly | An established weekly GLP-1 option |
Wegovy tablet | Semaglutide | Tablet | Once daily | Requires overnight fasting and careful timing around food, drink and other tablets |
Mounjaro | Tirzepatide | Injection | Once weekly | Acts on both GLP-1 and GIP receptors |
Foundayo | Orforglipron | Tablet | Once daily | Can be taken without food or water restrictions |
Wegovy contains semaglutide, a GLP-1 receptor agonist that can reduce hunger, increase fullness and decrease food cravings.
The injectable formulation is taken once weekly. Wegovy is also available as a once-daily tablet for adults who meet the relevant clinical criteria and prefer an oral treatment.
The tablet has specific administration requirements. It is taken whole on an empty stomach after fasting for at least eight hours, with a small amount of water. No food, drink or other oral medication should then be taken for at least 30 minutes, because this can reduce absorption.
Mounjaro contains tirzepatide and is taken as a once-weekly injection. It acts on both GLP-1 and GIP receptors, which are involved in appetite and metabolic regulation.
Clinical studies have generally shown greater average weight reduction with tirzepatide than with injectable semaglutide, but results vary and trial averages cannot predict an individual response. Effectiveness must be balanced against suitability, tolerability, cost and patient preference.
Foundayo contains orforglipron, a once-daily oral GLP-1 receptor agonist. It works through appetite-regulating pathways to increase fullness and reduce hunger and cravings.
Unlike the Wegovy tablet, Foundayo can be taken at any time of day without fasting or restrictions around food and water. This may be more practical for some patients.
As with other GLP-1 treatments, the dose is increased gradually to improve tolerability. Foundayo is a prescription-only medicine and requires the same careful assessment and monitoring as injectable treatment.
There is no single best option for everyone.
Weekly injections may suit patients who prefer not to remember a tablet every day. Tablets remove the need to inject, but Wegovy tablets have strict administration requirements and all oral treatments still require gradual dose increases and monitoring.
During consultation, we discuss:
Weight loss varies considerably. Factors include starting weight, dose tolerance, adherence, eating patterns, physical activity, sleep and underlying metabolic health.
Clinical-trial averages can help explain how treatments compare at a population level, but they are not guarantees. We focus on safe, sustainable progress and broader improvements in health rather than pursuing the fastest possible rate of weight loss.
Common side effects of GLP-1-based treatment include:
These effects are often most noticeable when treatment begins or the dose increases. Careful selection, gradual escalation and timely clinical review can improve tolerability.
Less common but potentially serious complications can occur. Patients are counselled about warning symptoms and when to stop treatment or seek urgent assessment. Treatment is not suitable during pregnancy, and additional precautions or alternative contraception may be needed with some medicines.
Medication should only be obtained from a registered pharmacy following an appropriate prescription. Products from unregulated sellers may be counterfeit or unsafe.
Medication can reduce hunger and cravings, but it does not replace nutrition, exercise or a long-term plan.
Our programme focuses on:
Weight loss includes a combination of body fat, water and lean tissue. Some loss of muscle can occur with medication, dieting, bariatric surgery or any other method that creates a sustained calorie deficit.
Preserving muscle matters because it supports strength, mobility, blood-sugar regulation, physical function and healthy ageing.
We therefore encourage:
The quality of weight loss matters as much as the number on the scales.
Weight concerns often exist alongside insulin resistance, prediabetes, fatty liver disease, high blood pressure or an adverse cholesterol profile.
Assessment may include HbA1c, glucose, liver function, cholesterol, blood pressure and body composition. These measures help us understand future health risk and track improvements that may occur even before substantial weight loss is visible.
For many patients, improving metabolic health ultimately matters more than reaching an arbitrary target weight.
Many women find weight management more difficult during perimenopause and menopause. Changes in oestrogen, sleep, stress, muscle mass, activity and fat distribution may all contribute.
HRT is not a weight-loss treatment, but improving symptoms such as poor sleep, hot flushes and reduced energy may make healthy routines easier to maintain. Weight-loss medication may also be considered when clinically appropriate.
Our approach considers hormonal health, metabolic risk, body composition, sleep and lifestyle rather than attributing menopausal weight gain to willpower.
Weight regain is common after diets and after stopping weight-loss medication. This is not necessarily a failure of motivation: weight loss can trigger persistent biological changes that increase appetite and encourage the body to return towards its previous weight.
Some patients may benefit from longer-term treatment, while others transition to a lower dose or a non-medication maintenance strategy. The right approach is individual and should be reviewed regularly.
From the outset, we discuss:
Regular follow-up allows us to monitor progress, manage side effects, adjust treatment and review metabolic health.
Our Weight Management Membership provides ongoing access to Dr Dan Wright and our nutrition team throughout the working week. Patients can seek advice about medication, nutrition, exercise, plateaus, side effects and maintenance without waiting for a formal review appointment.
The aim is to provide the clinical guidance and continuity needed to maximise safety and support sustainable results.
There is no single programme that is right for everyone. At The Wright Practice, we combine evidence-based obesity medicine with personalised general practice.
Our goal is not simply to help patients lose weight. It is to improve health, reduce future disease risk, preserve strength and develop a realistic strategy that can be maintained over the long term.
Wow! Dr. Dan was extremely knowledgeable and attentive to my health and well being. I’m so glad to have found him!
I have been going to Dr Wright for a number of years now. He is highly knowledgeable, compassionate, open minded and efficient, I couldn’t recommend him highly enough
I have been a patient of Doctor Dan for some time and continue to consult with him despite having left the UK. Dan has the enthusiasm and energy of a young man, whilst taking the holistic “physician” approach of an old school family doctor, equipped with the most modern insights and technology.
Dr Jain was great. Expert knowledge with practical advice
Options may include once-weekly injections or once-daily tablets. The clinically appropriate choice depends on your medical history, goals, previous treatment, side effects and preferences. Medication is recommended only after assessment.
Wegovy tablets contain semaglutide and must be taken after an overnight fast, followed by at least 30 minutes without food, drink or other tablets. Foundayo contains orforglipron and can be taken without restrictions relating to food or water.
These medicines have been assessed by the UK medicines regulator, but no treatment is risk-free or suitable for everyone. We assess contraindications, explain common and serious side effects, and provide ongoing monitoring.
Medication works best alongside sustainable eating habits. Smaller portions and avoiding very fatty meals can also reduce gastrointestinal side effects. We place particular emphasis on adequate nutrition and protein.
Yes, in most cases. Resistance exercise is particularly useful for preserving muscle, while cardiovascular exercise and general activity support physical and metabolic health.
Some weight regain is common because appetite-regulating mechanisms can re-emerge. A planned maintenance strategy can help, and longer-term treatment is appropriate for some patients.
Some patients notice reduced appetite or cravings within the first few weeks. Meaningful weight change usually occurs over months, but responses vary and treatment should not be judged solely by short-term results.
This is individual. Many patients continue for at least six to twelve months, while some benefit from longer treatment. Progress, safety and the maintenance plan are reviewed regularly.
The £95 monthly membership includes ongoing medical support, nutritional guidance and regular check-ins. Medication and the initial consultation are charged separately, with a minimum three-month commitment.
Support may include medical assessment, nutritional advice, exercise and muscle-preservation guidance, quarterly clinical reviews, side-effect management and ongoing telephone or email support between appointments.
The initial consultation is £195 and includes a detailed assessment of your medical history, weight history, lifestyle, treatment goals and the clinically appropriate options.
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